This upscale 435-room historic hotel (voted among the Top 10 Hotels in North America by Conde Nast Traveler) sits right in the middle of a ton of family-friendly activities and sights in the heart of Charleston's historic district. Located on the corners of King, Market and Meeting streets, Charleston Place is adjacent to the Old City Market, where women have sat for generations weaving sweetgrass basket creations to sell. It's also within walking distance of all of the historic district's sights and attractions and is surrounded by the district's centuries-old architecture, cobblestoned streets, intricate ironwork and general, all-round antebellum ambiance.

The hotel itself is quite grand, starting with the Italian marble lobby featuring a Georgian Open Arm staircase and a 12-foot hand-blown Venetian crystal chandelier. The hotel's tony spa, indoor/outdoor pool, three restaurants, club-level lounge and 24-hour room service will also not fail to make an impression. The likes of Richard Gere, Prince Charles, Oprah Winfrey and Julia Roberts have slept here, not to mention several U.S. presidents and even the emperor of Japan. No wonder it's held in high regard -- the London-based company that owns Charleston Place also owns the fabled luxury train known as the Venice Simplon-Orient-Express.

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